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Researchers from the University of East Anglia and Oxford Biodynamics have developed a new blood test that can reportedly detect chronic fatigue syndrome (ME/CFS) with up to 96% accuracy. The discovery could mark a major step forward in diagnosing a condition that has long been difficult to confirm through medical tests.The test identifies unique patterns in how DNA folds inside cells. These folding patterns, known as chromatin conformations, appear to differ between healthy people and those with ME/CFS. 

Scientists analyzed blood samples from 47 patients with severe ME/CFS and 61 healthy volunteers to reach their results.

Researchers found nearly 200 DNA pattern changes that were linked to immune and inflammation pathways, which may explain some of the symptoms seen in ME/CFS. They believe this method could provide a biological marker to confirm the disease and help reduce misdiagnosis.

Experts, however, caution that more research is needed before the test can be used in clinics. The study’s sample size was small, and it only included patients with severe symptoms. Larger studies are required to confirm how well the test works across different patient groups and conditions that cause similar fatigue.